Özet:

The importance of nutrition during childhood is recognized in the literature. It is known that nutritional insults in critical periods of development can program the metabolism for consequences that last until adulthood. The aim of the work was to evaluate the effects caused by overfeeding during lactation on the infant's metabolic parameters. For that, male rats were evaluated in the litter reduction model to simulate overfeeding in the reduced litters. The rats were kept in a controlled environment and weighed every two days, with euthanasia at 21 days, at weaning. The nasoanal length of the pups was measured, the main fat reserves were collected, as well as the liver, for weighing and evaluation of the biometric parameters. In addition, blood was collected from the puppies and the mothers' milk for biochemical analysis. The animals submitted to overfeeding showed an increase in total weight, as well as a major increase in their main fat reserves. In addition to the increase in weight, they showed metabolic dysfunction, such as increased levels of total cholesterol and triglycerides. The biochemical composition of the milk showed no difference between the groups analyzed. It is concluded that rats overfed during lactation present metabolic and biometric disorders at 21 days of life. The findings reinforce the importance of healthy eating at the beginning of life to avoid metabolic disorders at this stage and in adult life.

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