Özet:

Purpose: In this study, we aimed at investigating the diagnostic value of prostate cancer (Serbest/Total PSA)/PSAD and FPSA/PSAD for the detection of prostate cancer in the Turkish population. Instruments-Methods: In the period from January 2007 to December 2017, patients with prostate-specific antigen (PSA) values ranging from 4 to 10 ng/dl were retropestically examined. The data was collected from patients divided into prostate cancer (PCa) and benign prostate hyperplasia (BPH) groups according to the results of prostate biopsy. Values such as prostate volume (PV), free PSA (FPSA), total PSA (TPSA), free-total PSA ratio (F/T), PSA intensity (PSAD), (F/T)/PSAD and FPSA/PSAD were recorded and compared among the groups. The availability of these values in the prediction of prostate cancer has been studied. The SPSS 22.0 software was used to calculate the "Receiver Operating Characteristic Curve" (ROC curve) and respectively sensitivity, specificity and positive forecast values (PPV) and negative forecast values (NPV). The study included a total of 327 patients (131 PCa and 196 BPH). (F/T)/PSAD and FPSA/PSAD’s sensitivity and specificity values were better than PSAD, PSA, F/T. Depending on the optimal cutting value, the sensitivity of (F/T)/PSAD and FPSA/PSAD was similar. The negative forecast values of F/T, (F/T)/PSAD and FPSA/PSAD were similar. The logistical regression model using the age, PV, FPSA/PSAD and (F/T)/PSAD combinations alone showed a higher AUC than each. The result: FPSA/PSAD and (F/T)/PSAD, which are relatively new parameters, are parameters with similar diagnosis accuracy in the preview of prostate cancer. These two reviewed parameters have a higher sensitivity and specificity than F/T and PSAD alone. However, more research is needed to evaluate the effectiveness of the diagnostic value of these parameters.