Özet:

Research related to micobiome claims to find associations to disease processes of many organ systems. Fat tissue, kidneys, heart and vasculature, intestines and even brain tissue is affected by dysbiosis of gut flora. With the advance of studies and their qualities on topic, research evolved from being focused solely on microbiome itself to encompassing metabolites penetrating into serum and immune response demonstrated by host. Effect of such a molecular invasion of body results in a low grade inflammation and chronic diseases such as metabolic syndrome, diabetes mellitus, chronic kidney disease and cardiovascular disease ensues. With such a vast gamut of diseases and pathologic conditions related to microbiome, it should come as no surprise that there have been attempts at treatment of dysbiosis with methods including flora transfer from healthy individuals. This review will focus on these disease states and how they are affected by dysbiosis. Specific metabolites such as indoxyl sulfate, p-cresyl sulfate or trimethylamine N-oxide are increased in a dysbiotic state and affect the pathological course of chronic kidney disease and atherosclerosis. The disease state host is in has effect on permeability of gut barriers and will create dysbiosis such as in uremia related epithelial barrier degradation due to chronic kidney disease.

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