Abstract:

Objective: In chronic hepatitis B patients, non-invasive tests have been revealed in recent years, which are believed to be an alternative to liver biopsy to predict liver histology. This study was aimed at investigating the relationship between the degree of fibrosis in the hepatic biopsy of HBeAg-negative chronic hepatitis B patients and the basic serum biochemical parameters. Tools and Methods: In the study, chronic hepatitis B diagnosis and patients over the age of 18 followed between 1 August 2012 and 31 August 2019 in our hospital’s Infectious Diseases Clinic, HBeAg negative and HBV-DNA levels >2000 IU/mL and hepatic biopsy were included. By scanning the patient files, the demographic characteristics of individuals, laboratory results were recorded and repeated patients were not taken to evaluate. Patients were grouped according to the Ishak fibrosis score and divided into three groups in the form of those with light fibrosis (F≤2), medium fibrosis (F3-4), and sirosis (F5-6). Fibrosis scores 5-6 were dismissed due to the lack of numbers. The study included 242 patients. 154 of the patients (63.6 percent) were male and 88 (36.4 percent) female, with an average age of 40.84±11.06. Fibrosis scores were higher in male sex and older. As the score and stage progress, higher serum area aminotransferase, aspartate aminotransferase, protrombin time, gamma glutamil transpeptidase, alpha-fetoprotein and HBV-DNA levels (P<0.001) and lower trombocytes (P<0.) in patients. 001 was found. Result: These parameters can predict advanced phase fibrosis in patients with chronic hepatitis B. Non-invasive tests reduce the need for hepatic biopsy but do not eliminate it. They should be used with a hepatic biopsy.

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