Abstract:

The present study is to develop and evaluate an ethosomal gel formulation of Zanamavir . It aims to provide a topical treatment for many viral infections that affect the skin. Administration of medications topically having the facility of delivering a high concentration of the drug to the skin than would be possible with systemic therapy. Topical administration of drugs is better for local action and the efficiency of the topically administered drug is increased with liposome, proliposomes and ethosomes. Recently, it was found that ethosomal carriers were phospholipid vesicular systems having relatively high concentrations of alcohol, enhances dermal and transdermal delivery of both lipophilic as well as hydrophilic molecules. Ethosomes were formulated using phospholipid, ethanol, polyethylene glycol and purified water by cold method. Ethosomes were evaluated for vesicle size, shape, optical microscopy, entrapment efficiency and invitro release study. ZEF7 have better drug entrapment efficiency than the other formulation. The best formulation (ZEF7) was used to prepare gel by using carbopol 934 as a gelling agent. The ethosomes were entrapped in gel matrix of carbopol 980 in different concentration 0.5%, 1.00% and 1.5% w/w. FT-IR studies revealed no interaction between the drug and excipients. The formulated gel formulation was evaluated with parameter pH, viscosity, spreadability, in-vitro release test, washability, extrudability study and stability studies. The formulation ZEF7 have better in-vitro drug release profile which contains carbopol 980 concentration 1.5 %w/w. The present work also focuses on making the formulation more pharmaceutically acceptable

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