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Basal cell carcinomas are slow-growing, locally aggressive tumors arising from the interfollicular epidermis and/or hair follicle. Here, a 74-year-old man presented with an irregular nodule 2.5x2 cm in size on the left ala of the nose for 3 years. On light microscopy the signet ring cell configuration was observed among neoplastic cells focally (in some areas). The most prominent feature was cells containing large eosinophilic, pink, eccentric intracytoplasmic inclusions that compress the nuclei to the cell border. The cell inclusions did not stain with periodic acid schiff and alcian blue pH 2.5. The tumor cells were positive for Ber-EP4 but negative for S-100.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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