Özet:

Purpose: The second series radiotherapy (ISRT) after local and/or regional repetition is to retrospective our treatment results in patients with nasopharynx cancer. Instruments and Methods: Second series of radiotherapy was applied and included in the study to 27 of 44 patients with local and/or regional repetition after receiving definite radiotherapy ± chemotherapy for nasopharynx cancer between 1991 and 2018. Results: Median follow-up after the first treatment is 49 (13-255) months. The period of repetition after primary radiation therapy is medium 18 months (3-216) and 20 (74) patients have local, 5 (19%) patients have regional and 2 (7.4) local and regional repetition. ISRT was applied to 16 (%59) patients conventional, 5 (%18) patients conformal, 4(%11) patients using VMAT and 2(%7) patients using stereo-taxic radiotherapy technique, median 30 (4-35) fraction and 2 Gy (2-7) fraction doses will be the median total dose of 60 Gy (15-70). In the post-RT response assessment, 7 (%26) full response, 11 (%41) partial response and 9 (%33) progressions were detected in patients. The overall survival rate of two to five years is 85% to 47% respectively, and 44% to 24% after repetition. The progressive survival rates of 2 and 5 years after MRI are 34% and 20%. In the single variable analysis; for general survival, the time passed until repetition (p< 0,001), the ISRT dose (p=0,048); in the PSK, the ISRT technique (p= 0,01), the time passed until renewal (p<0,001), the ISRT dose (p=0,002) was significantly determined. In the multi-variable analysis, the time only passed until repetition (p<0,001) was statistically meaningful. The result: Despite the limited number of patients, survival rates were found satisfying. With the help of technological developments in the future, better survival rates will be achieved with fewer side effects in such high-risk diseases.

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