Abstract:

Purpose: This retrospective study was aimed at determining the frequency of endometrial cancer in patients diagnosed with endometrial hyperplasia and operated, as well as assessing the harmony between preoperative diagnosis and frozen examination and the final result of pathology. Instrument and Method: The archive scan in the electronic environment was carried out between January 2010 and January 2017 with the diagnosis of endometrial hyperplasia (atypical or unatypical) and the examination findings of patients operated in our hospital, the surgical notes and all pathological results were evaluated retrospectively. The demographic and clinical characteristics of patients (age, menopause, parity, HIV, diabetes, hypertension, smoking) have recorded the results of the surgical procedure and pathology. Results: A total of 195 patients with endometrial hyperplasia diagnosed with surgical treatment reached the records were taken to study. In 112 patients, atypical hyperplasia was present, and in 83 there was atypical hyperplasia. Atypical hyperplasia, the result of the intraoperative frozen of the histerectomic material in cases, was malignant in 38 (33.9%) patients, and benign in 74 (66.1%) patients. In the atypical hyperplasia group, 36 (94.7%) of 38 patients who received the frozen result malign were to have the paraffin examination malign, while 2 (5.3%) of patients received the result benign. Again, in the atypical group, the result of frozen was benign in 74 patients with 69 (93.2) and the final result of pathology was benign in 5 (6.8) patients with endometrial cancer. Compared to the result of the paraphine cuts of the patient’s 112 atipical hyperplasia in the Frozen study, the sensitivity, specificity, positive predictive value and negative predictive value of the frozen assessment were 87,8, 97,1, 94,7 and 93,2 per cent respectively. The study of paraphine was benign in 73 (93.7%) of 75 patients who were not frozen in the group of atypistic hyperplasia, while in 2 (2.7%) patients endometrial carcinoma was identified. The result: Atypical endometrial hyperplasia cases, the incidence of endometrial cancer is high at the same time. Intraoperative frozen assessment in these patients has a critical importance in determining the procedure to be applied and should be routine in all patients.

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