Özet:

The aim of this study is to evaluate the dry eye outcomes and tear osmolarity of patients followed by a unilateral herpetic keratitis diagnosis and to examine whether these outcomes exist in other non-sickness favourites. In this prospective study, the eye (Group 1) of 40 patients followed with a unilateral herpetic keratitis diagnosis in the cornea unit of our clinic and the other eye (Group 2) with a eye (Group 3) of 40 control phenomena. Detailed eye examinations of the incidents and time of tear break (GYKZ), Schirmer tests and tear osmolarities, measured by the osmolarity device, were recorded. All sub- and upper cover meibographs were taken and the rate of losses of the meibomian gland was manually measured. Results: The average age of patients in the study group (22 men, 18 women) was 53,5 ± 9,6 years, while the average age of the control group (21 men, 19 women) was 52,4 ± 9,2 years (p>0,05). The Osmolarity score was 307, 5±6,9 and 303,4 ± 7,8 mOsm/L in Group 1 and 2 respectively, while in Group 3 it was 295,5 ± 6,3 mOsm/L (p<0,05). The Schirmer test score and GYKZ were 8.2 ± 3.2 mm/5 min and 5.9 ± 2.1 s in Group 1 respectively; 10.5 ± 3.5 mm/5 min and 8.5 ± 3.9 s in Group 2 respectively, while 14.6 ± 2.3 mm/5 min and 12.1 ± 2.4 s in control group respectively (p < 0.05 and p < 0.05 respectively). There was no statistically significant difference between the groups in terms of meibomian gland loss (p>0,05). The result: Unilateral stromal herpetic keratitis causes bilateral dry eye outcomes, which are more severe than preferred for keratitis. In this study, it was aimed to evaluate the dry eye findings and tear osmolarities of patients with unilateral herpetic keratitis and to investigate whether these findings were present in the fellow eyes without disease. Material and Methods: In this prospective study, 40 patients with unilateral herpetic keratitis were subdivided as eyes with keratitis (Group 1) and fellow healthy eyes (Group 2) and one eye of 40 control subjects were evaluated. Detailed ophthalmological examinations of the cases and tear osmolarities measured with osmolarity instrument, tear break up time (TBUT), and Schirmer test scores were recorded. All subjects underwent lower and upper led meibography and meibomian gland loss rates were measured manually. Results: The average age of patients in the study group (22 males, 18 females) was 53.5±9.6 years, while the average age of the control group (21 males, 19 females) was 52.4±9.2 years (p>0.05 ). Osmolarity score was 307.5±6.9 and 303.4±7.8 in groups 1 and 2, respectively and 295.5±6.3 mOsm / L in the control group (p<0.05). Schirmer test score and TBUT were 8.2 ± 3.2mm/5min and 5.9±2.1 sec in Group1; 10.5±3.5mm/ 5min and 8.5±3.9 sec in Group 2 and 14.6±2.3mm/5min and 12.1±2.4 sec in the control group respectively (both, p<0.05). There was no significant difference in meibomian gland loss rates between groups (p>0.05). Conclusion: Unilateral stromal herpetic keratitis leads to bilateral dry eye, with more severe keratitis in the affected eye. Keywords: Herpes Keratitis; Dry Eye; Meibography; Osmolarity.

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