Özet:

INTRODUCTION: Macrovascular and microvascular complications are major responsible for mortality and morbidity that develop over time in diabetic patients. MPV and PDW levels can be reduced with good glycemic control and thus prevented or delayed vascular complications in patients. This study aimed to evaluate the relationship between HbA1c and increased MPV, PDW levels in Type 2 DM patients. METHODS: The study was conducted retrospectively to demographic information and laboratory records of patients over 18 years old who were admitted to Ankara Atat�rk Training and Research Hospital Family Medicine and Endotem policlinics for general health check-up and diagnosed with Type 2 DM between June 2016 and April 2017. RESULTS: A total of 112 diabetic, 33 non-diabetic criteria are met; 145 patients with biochemical data were included in the study. The control group (n = 33) was divided into 2 groups, diabetic patient group HbA1c≤ 7% (n = 46) and HbA1c> 7% (n = 66). There was a statistically significant positive correlation was found between MPV and PDW values according to HbA1c values (p1 = 0.001, p2 = 0.001, p3 =0.001, respectively). DISCUSSION AND CONCLUSION: Current glycemic dysregulation cause to increase in platelet activation markers such as MPV and PDW, which cause vascular complications. As a result of our study, it is thought that MPV and PDW can be used as simple and low-cost tests to monitor DM progression and thus to prevent and screen vascular complications in primary health care. Early diagnosis and appropriate treatment may delay the development and progression of diabetic vascular complications.

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