Abstract:

Background and Aims: Polycystic ovarian syndrome is the most frequently seen endocrine disease in women of reproductive age. Functional dyspepsia is a functional gastrointestinal disorder that is commonly seen in the general population, accompanied by dyspeptic symptoms without an organic cause. Previous studies have not investigated the frequency of functional dyspepsia in patients with polycystic ovarian syndrome and the relationship between them. In this study, we aimed to determine the frequency of functional dyspepsia in patients with polycystic ovarian syndrome and to investigate the relationship between them. Materials and Methods: Our study was prospectively planned, and 73 patients with polycystic ovarian syndrome and 67 healthy control subjects of reproductive age were included. Gastrointestinal symptoms were detected via survey conducted on these subjects. Height and weight values of the subjects were recorded, and serum fasting glucose, insulin, cortisol, prolactin, thyroid stimulating hormone, follicle stimulating hormone, luteinizing hormone, total testosterone, and dehydroepiandrosterone sulfate levels were measured. Homeostasis model assessment of insulin resistance and body mass index values of the subjects were calculated. Results: There was no significant difference in age between the study group and the healthy control group (22.1±4.1 vs. 23.5±5.1 years, respectively, p > 0.05). When the groups were compared in terms of serum total testosterone, dehydroepiandrosterone sulfate, and luteinizing hormone levels, the differences were found to be statistically significant (p = 0.001, p = 0.001, and p = 0.038, respectively). Functional dyspepsia was present in 38 (52.1%) of the 73 patients with polycystic ovarian syndrome and 16 of the 67 (23.9%) patients in the control group. The frequency of functional dyspepsia was higher in patients with polycystic ovarian syndrome than in healthy control subjects (p = 0.006). In patients with polycystic ovarian syndrome with functional dyspepsia, when functional dyspepsia subgroups were compared, postprandial distress syndrome was more frequent than in the healthy control group (p < 0.05), while no statistically significant difference was found between the healthy control group and the group with epigastric pain syndrome (p > 0.05). There was no significant difference in body mass index, serum fasting glucose, insulin, cortisol, prolactin, thyroid stimulating hormone, follicle stimulating hormone, and homeostasis model assessment of insulin resistance index in polycystic ovarian syndrome when patients were compared with the healthy control group (p > 0.05). Conclusion: In patients with polycystic ovarian syndrome, the frequency of functional dyspepsia and its subgroup, postprandial distress syndrome, was found to be higher than in the healthy control group. In patients with polycystic ovarian syndrome, the cause of the frequent cooccurrence of functional dyspepsia and its subgroup, postprandial distress syndrome, was thought to be hyperandrogenism.

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