Abstract:

Objectives: Hemorrhoidal disease is a common and uncomfortable condition affecting people worldwide, primarily in the lower rectal region. This study explores the relationship between hemorrhoidal disease and the levels of homocysteine, folic acid, vitamin B12, zinc, and copper in men. Methods: A prospective study included 38 male patients with internal hemorrhoids (Group I) and 38 healthy male individuals (Group II). Venous blood samples were collected after a 12-hour fast and analyzed for homocysteine, folic acid, vitamin B12, zinc, and copper levels. Statistical analyses, including the Kolmogorov-Smirnov test, Mann-Whitney U or Two-Sample t-test, Receiver Operating Characteristic (ROC) analysis, and Multivariate Binary Logistic regression, were performed. Results: Group I and Group II had similar age and body mass index (BMI). Homocysteine and copper levels were significantly higher in Group I, while folic acid and vitamin B12 levels were significantly lower. High homocysteine levels (≥11.2 µmol/L) had a sensitivity of 92.11%, while low vitamin B12 (<114) and high copper (≥1004) levels exhibited high specificity (97.37% and 86.8%, respectively). An increase of one unit in vitamin B12 was associated with a 1.04% decrease in hemorrhoid occurrence. Conclusion: This study suggests that evaluating homocysteine, copper, folate, and vitamin B12 levels may be valuable in patients with or at risk of hemorrhoidal disease. Future research should include larger, more diverse samples to enhance the generalizability of these findings.

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