Abstract:

Introduction: Vitamin D is considered a steroid hormone with a broad-spectrum human body activity. Objective: To evaluate the association between vitamin D deficiency and metabolic syndrome in postmenopausal women. Materials and methods: Retrospective cross-sectional study, between August 2013 and August 2014, with 177 postmenopausal women attended at the endocrinology and gynecology outpatient clinics of a reference hospital in the city of Rio de Janeiro (RJ). Questionnaire applied with clinical and demographic data, physical and anthropometric examination (weight, height, body mass index and waist circumference). Blood metabolites: 25(OH)D, insulin, estradiol, glucose, total cholesterol, high density lipoprotein (HDL-cholesterol) and low-density lipoprotein (LDL-cholesterol) and triglycerides. 25(OH)D reference: sufficient ≥ 30 ng/mL, insufficient 20-29 ng/mL and deficient <20 ng/mL. Metabolic syndrome diagnosis was done by National Cholesterol Education Program - Adult Treatment Panel III. Results and discussion: Metabolic syndrome prevalence was 56.5% and hypovitaminosis D 48.0%. HOMA-IR was highest (p=0.0457) in the groups with hypovitaminosis D; triglycerides (p=0.0348) and HOMA-IR (p=0.0189) showed significant correlation with 25(OH)D. Women with hypovitaminosis D had an increased chance of elevated metabolic syndrome (OR 1.099), waist circumference (OR 1.250) and blood pressure (OR 1.212) increased. There was an inverse association between 25(OH)D with hypertriglyceridemia (OR 0.9044), high HDL-cholesterol (OR 0.8409) and hyperglycemia (OR 0.5950). Conclusion: Postmenopausal women with hypovitaminosis D had a higher risk of metabolic syndrome, increased waist circumference and blood pressure.

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