Abstract:

Background: Dengue Hemorrhagic Fever (DHF) is a main health problem in Indonesia, particularly in Bali. World Health Organization (WHO) reported Indonesia as the major contributor of DHF cases in the Southeast Asia and according to Indonesia national statistic report in 2010, Bali was the province with the highest incidence of DHF in Indonesia. Case presentation: A 28 years old woman gravida 2 (para 0, abortus 1) at near term (35 weeks 2 days) gestational age, with threatened preterm delivery and premature rupture of membrane was admitted to Sanglah Hospital due to high probability of dengue infection (fever day 6) with warning signs (hemoconcentration) and thrombocytopenia (23,000/mm3). The dengue specific IgM and IgG antibodies were positive on the seventh day. On the progress, although the number of the platelet count tended to increase (WBC:9.99/mm3; Hb:14,3g/dL; Hct:44.6%; Plt:49,2x103/mm3), the patient developed antepartum haemorrhage due to placental abruption grade 2, and decided to have the Cesarean Section (CS) code green. No other maternal complications found, including bleeding from the surgical wound. A preterm (35-36 weeks) baby was born with birthweight of 2500 gram and moderate asphyxia. On the second day, the baby’s serial blood counts showed a gradual rise in the haematocrit (>20% of baseline value) and a decline in platelet counts. DENV-4 dengue was detected in the infant’s blood (serum) on first day care using the polymerase chain reaction (PCR). The baby’s dengue NS1 antigen and the dengue specific IgG antibodies was positive on first day care while the dengue specific IgM was positive on the seventh day.             Mother was discharged on the third day post operative, while the baby was discharged on the 10th day, in a good condition. Conclusion: Symptomatic dengue infection during pregnancy increase the risk of preterm labor, bleeding, and low birthweight newborn. Secondary dengue infection are likely to have severe symptoms than the primary dengue infection. The vertical transmission of Dengue infection is rarely reported and the mechanism of transmission of the infection in the peripartum period remains unclear.

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