Abstract:

Aim: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age. Clinical and biochemical characteristics are similar to metabolic syndrome. Insulin resistance in patients with metabolic syndrome is associated with serum uric acid levels. In our study, we aimed to investigate the relationship between serum uric acid levels and clinical and laboratory in PCOS patients. Material and Method: 172 PCOS patients and, 34 years old, body mass index (BMI) matching control group of a total 206 cases attended to endocrinology outpatient clinic were included in the study. At early follicular phase, blood samples were taken after a 12-hour fasting period. Basal serum hormone levels were measured by immunoassay. Results: Uric acid levels was significantly higher in PCOS than control group (4.25 ± 1.07 PCOS, 3.7 ± 0.79 control, P = 0,048). Uric acid levels were positively correlated with BMI, total cholesterol, insulin, cycle time, Feriman Gallwey score and negatively correlated with HDL cholesterol levels. Uric acid levels were 2 times higher than in PCOS group independent to age and BMI with multivariate logistic regression. Conclusion: Uric acid levels in study group was significantly higher independent to age and BMI. Cardiovascular risk factors; LDL, insulin, triglycerides, BMI was positively correlated with uric acid in PCOS group. Clinical indicators; Feriman Gallwey score and cycle time was also positively correlated. Elevated uric acid levels in PCOS patients may be an independent risk factor for cardiovascular disease, may show negative results in the clinic. Key words: cardiovascular disease, polycystic ovary syndrome, uric acid,

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