Abstract:

The aim of this study was to compare the effects of methylprednisolone, a non-steroidal anti-inflammatory drug (NSAID) and a steroid agent, on the prevention of intraabdominal adhesions in rats. In the study, 21 of the 2-3-month female Wistar albino rat were used. The rats were divided into three groups in each group to be seven. After a two-cm laparatomy, a adhesive model was created by making a cutting process until serous bleeding occurs on the abdominal wall and secular surface. The wounds were closed according to the routine surgical rules. Rats in the first, second and third groups were given intraperitoneally for 5 days, respectively, 7 mL/kg of serum physiological (control), 5 mg/kg of meloxicam and 10 mg/kg of methylprednisolone. The rocks were evaluated after fourteen days after being overwhelmed. In the macroscopic assessment, the formation of adezyon in the treatment groups was less observed than in the control group (P=0.016). In the histopathological controls, the severity of the fire was more evident in the control group. Fibrosis was most apparently observed in the control group (P=0.016). Immunohistochemical assessments found that the number of IL-1 positive cells in the control group was greater than in the treatment groups (P=0.016). As a result, it has been found that meloxicam and methylprednisolone can be used in the prevention of intraabdominal adhesions.

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