Abstract:

Objective: Central nervous system infections are infections with high morbidity and mortality that require urgent diagnosis and treatment. We aimed to help patient management by examining the CNS infections followed in our hospital. Methods: The data of 56 patients who were diagnosed with SSS infection between 2013 and 2020 in Ümraniye Training and Research Hospital were evaluated retrospectively. Results: The clinical classification of 56 patients diagnosed with CNS infection in seven years was examined. Bacterial meningitis (51.8%) was the most common type, aseptic meningitis- encephalitis (35.7%) was in the second order and followed by tuberculosis meningitis (12.5%). 87.2 % of the patient's CSF culture was sterile, S. pneumonia (10.3%) and E. coli (6.8%) were detected in CSF cultere. HSV1 PCR positivity was 10% in aseptic meningitis and encephalitis. Empirically, antiviral and antibiotic treatment was initiated together with 21.4%. Conclusion: In our study, the proportion of patients who could not distinguish between encephalitis and meningitis at the time of application is remarkable. In addition, it was observed that the agents could not be isolated in the majority of patients. It was concluded that the distribution of agents used in general empirical treatments can change the frequency order. Knowing the distribution of causative agents of CNS infections in the management of patients guides empirical treatment selection.

Keywords: