Özet:

This study was carried out to determine the influence of ghrelin administration on some haematologic parameters in rats. Forty male Sprague Dawley rats were equally divided into two groups, control group (1 ml physiological saline s.c., for 5 days) and experimental group (ghrelin, s.c., 10 nmol/kg/day, for 5 days). From each animal, blood samples were taken 24 h after the end of treatment, and some hematological parameters were evaluated: total erythrocyte and leukocyte count, hemoglobin concentration, hematocrit value, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and mean corpuscular valume, and leukocyte differential counts. Lymphocyte percentage was increased (p<0.05), while neutrophil percentage was decreased (p<0.05) due to ghrelin administration. On the other hand, total erythrocyte and leukocyte count, hemoglobin concentration, hematocrit value, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean corpuscular valume, and other differential leucocyte counts (monocytes, eosinophils, and basophils) were not affected by ghrelin administration. As a result, it was determined that ghrelin administration to rats may increase lymphocyte ratio by stimulating lymphopoesis

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