Özet:

A synchronous definition of paracetamol and amoxicillin quantities in pharmaceutical formulations was performed using spectrophotometric methods. Principal component regression (PCR) and partial least squares regression (PLS) were used as multivariate calibration techniques. Spectrophotometric-chemometric methods were used for the simultaneous quantification of paracetamol and amoxicillin in the laboratory prepared mixtures and in the drug tablets without any requirements for a prior separation. The linearity of the calibration curves for each active substance in the synthetic mixtures demonstrated that concentration ranges were appropriate (r2>0.9997). The investigation of the accuracy and repeatability of the two methods resulted in high recovery rates and lower standard deviation values. Achieving high recovery and low standard deviation values, this study encouraged us to proceed further in pharmaceutical assay. The recommended methods are highly sensitive and precise as these methods have been successfully applied to quantify active substances in pharmaceutical samples.

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