Özet:

Aim: To define the effect of clinicopathological characteristics of patients with malign mesothelioma (MM) on overall survival. Materials and Methods: Forty-one patients diagnosed with MM who were treated at the medical oncology clinics between 2008 to 2020 were assessed. Clinicopathological characteristics and overall survival (OS) of patients, and treatment modalities analyzed. Results: Forty-one patients were included in this study. The median age of patients was 63.5. At a median follow-up of 16.7 (range:0.5-172.6) months, 78%(32) of patients died. Median OS was 17.6 months. 65.9% (27) of patients had stage 3 and 29.3% (12) had stage 4 diseases when they were diagnosed. Most of the patients were diagnosed at the advanced stage (Stages 3-4) (95.2%). The median OS of patients diagnosed with epithelioid histopathologic subtype was 32.4 months, while the median OS of those with sarcomatoid was 5.23 months, while the median OS of biphasic was 4.33 months. This difference was statistically significant (p<0.001). When examined in terms of treatment, there was a statistically significant difference between OSs (p=0.010). The Median OS of patients treated with chemotherapy (14.4 months) was worse than with radiotherapy-chemotherapy (42.8 months) and with surgery-chemotherapy (21.4 months). In Cox regression analysis, when sex, location, smoking, histopathological subtype, and laterality were taken together, the pathological subtype was an independent risk factor effects on survival. The sarcomatoid subtype increased death risk by 7.2 times compared to epithelioid (p=0.004), biphasic subtype increased death risk by 8.1 times compared to epithelioid (p=0.004). Conclusion: The etiology of MM is environmental exposure to asbestos or erionite in Turkey. Epitheloid histopathology and treatment with surgery or radiotherapy in diagnosed early stages of MM can prolong the OS of patients.

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