Özet:

Advanced glycation products AGEs are heterogeneous compounds produced endogenically from non-enzimatic glycation of proteins, lipids and nucleic acids. In physiological conditions, AGEs can be formed in all tissues and body fluids. AGEs, which are part of normal metabolism, can also be taken into the organism exogenously. It is explained that AGEs affect the body by two separate mechanisms. The first of these mechanisms is the cross-connection of body proteins, and the second is the interaction with the receptors of AGE. Researchers report that AGEs have a positive relationship between serum concentration and type 1 and type 2 diabetes. This relationship is related to the severity and progress of complications of diabetes, such as microvascular and macrovascular complications, inflammation and an increase in indicators of endothelial dysfunction. Diabetes, as well as oxidative stress, inflammation, obesity, hypertension, polycystic over syndrome are mentioned on the effects of AGEs in the ageing process. Although studies on healthy individuals have achieved different results, it has been found that low-AGE diet affects less biochemical indicators in healthy individuals than diabetes patients. The aim of this collection is to discuss the role of diet-based AGEs in the formation and development of diseases and their potential effects on health.

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