Abstract:

Objective: This study aims to determine the antibiotic resistance status and the presence of extended-spectrum beta-lactamase (ESBL) of E. coli, a causative agent of urinary tract infection.  Materials and Methods: The study included urine cultures admitted to the microbiology laboratory between January 2019 and April 2021. The susceptibility tests of E. coli strains isolated from urine cultures were obtained retrospectively. The evaluation was determined by the disk diffusion method of Kirby-Bauer according to Clinical and Laboratory Standards Institute (CLSI) criteria. Patient data were obtained from hospital records. Results: 805 microorganisms were isolated from 6216 urine cultures. Of the 805 microorganisms, 525 (65.21%) were E. coli. In parallel with the increasing age in men, the frequency of urinary tract infections also increased. Resistance rate of strains against cephalothin, ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, trimethoprim-sulfamethoxazole, amikacin, nitrofurantoin, imipenem and meropenem were 80.0%, 68.9%, 47.9%, 37.9%, 31.24%, 2.1%, 1.7%, 0.76% and 0.57% respectively. Extended spectrum beta-lactamase (ESBL) was detected in 86 (16.3%) of the strains. Conclusions: According to our center, antibiotic resistance is increasingly common in E. coli uropathogens. This suggests that further microbiological research is becoming even more important in planning rational antibiotic and infection treatment.

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