Özet:

There are some prognostic factors for the pre-operative prediction of organ confined prostatic carcinoma. The mostl accepted ones include preoperative blood PSA level, clinical stage and Gleason score. But, the predictive values of these factors are not very effective. So, we need more efficient prognostic factors. One of the most important factor to be investigated is the insulin like growth factor (IGF). There are two peptide hormones in IGF family: IGF-1 and IGF-2. IGF-1 is mitogen for human prostate cells. Its activity is regulated by IGF-binding proteins (IGFBP). IGFBP-3 is the most effective one which regulates prostatic activity. In this study, we investigated the expression of IGFBP-3 in prostatic cancer specimens, and its relation to pathological stage and prognosis. For this purpose, 38 patients which were diagnosed as localized prostate cancer and underwent radical prostatectomy were investigated. Tissue samples of radical prostatectomy specimens were examined by immunohistochemistry for detection of IGFBP-3 expression. As a result of immunohistocehemical study IGFBP-3 expression was decreased in the tumoral tissues whereas increased in BPH tissues. Expression also decreased in the BPH tissues closer to the tumoral areas and increased in BPH tissues away from the tumoral area. As a conclusion, we found that IGFBP-3 may have an important role in the development of prostate cancer. But, examining the tissue expression by immunohistochemistry do not give any additional benefit to existing methods for prediction of pathological stage and prognosis.

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