Abstract:

Background: Comparison of the Helicobacter Pylori (HP) eradication rate between classicaltriple therapy and bismuth added into the classical therapy on the HP positive patients with peptic ulcer is aimed. Materials and Methods: Sixty patients whom gastric and/or duodenal ulcer (peptic ulcer) was detected by endoscopy as well as who presented positive results in any of histopathology, urea breath test or HP antigen in the stool between January 2012 and January 2013 were included into the study prospectively. Classical triple therapy was applied to the patients in Group 1 (n=30) whereas classical triple therapy +bismuth were applied to the patients in group 2 (n=30) Therapeutic efficiency of both groups were compared statistically after 3 months. Results: HP antigen detection in the stool revealed eradication rates of 83.3 % and 73.3 % in Group 1 and Group 2, respectively. There was not any difference for therapeutic efficiency between both groups by the evaluation through HP antigen detection in the stool (p=0.532). Urea breath test determined eradication rates of 56.7 % and 53.3 % in Group 1 and Group 2, respectively. No difference was detected for therapeutic efficiency between both groups by the evaluation through urea breath test (p=0.795). Eradication rates by HP antigen test were more than rates by urea breath test for all patients treated; this difference was statistically significant (p=0.011). Conclusion: No difference was detected between classical triple therapy and classical triple therapy + bismuth therapy in terms of eradication. Therefore, the therapy should be planned by considering clarithromycin resistance. Furthermore, a significant difference was detected between Hp antigen in the stool and urea breath test for evaluation of therapeutic efficiency after the therapy and rate of eradication by HP antigen detection in the stool seems higher. Key words: Helicobacter pylori, Classical triple therapy, Bismuth