Özet:

Objective: Schizophrenia is a neurodevelopmental disorder characterized by positive, negative, affective and cognitive symptoms. Numerous studies have been conducted to elucidate the etiology of schizophrenia. Recent studies have focused on the relationship between vitamin D [(25(OH)D] levels and schizophrenia. In this study, the relationship between vitamin D levels and symptom severity in schizophrenia patients was investigated. Material and Methods: A total of 93 patients registered in Rize State Hospital Community Mental Health Center were included in this study. To determine the vitamin D levels of the participants, the 25(OH)D form of vitamin D, which has the highest concentration in circulation, was used. Detected vitamin D values were compared with the Scale for the Assessment of Negative Symptoms (SANS), the Scale for the Assessment of Positive Symptoms (SAPS), Calgary Depression Scale (CDS) mean scores and sociodemographic data. Results: In our study, vitamin D levels below optimal levels were found in approximately 61.3% of schizophrenia patients. 23.7% of the participants had vitamin D deficiency and 37.6% had vitamin D insufficiency. Considering the relationship between mean scale scores and vitamin D levels, no significant relationship was found between SANS and SAPS scores and vitamin D levels. A statistically significant relationship was found between CDS scores and vitamin D levels. In the group with vitamin D deficiency, CDS scores were significantly higher than the other groups (p: 0.001). Conclusion: In our study, vitamin D levels below optimal levels were found in the majority of patients with schizophrenia. It was observed that low vitamin D levels detected were also associated with depressive symptoms.

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