Abstract:

INTRODUCTION AND OBJECTIVE: Insufficient intake of vitamin D negatively affects bone mineralization and cycle. Changes in the mother’s bone cycle during pregnancy cause changes in the bone mineral content of the fetus. This study aims to identify the relationship between the factors affecting the metabolism of vitamin D, which are determining on fetal bone mineralization, biochemical bone indicators and the bone structure assessed by quantitative ultrasound in newborns. Method and Requirements: 90 term baby and mother born at Celal Bayar University School of Medicine was taken to study. Serum calcium, phosphorus, alkaline phosphatase, bone alkaline phosphatase, 1,25(OH)2D, 25(OH)D, parathyroid hormone and osteocalcin levels were measured. In the first 96 hours of life, tibial measurements were performed with quantitative ultrasound device. The average mother levels of 25(OH)D and 1.25(OH)2D were determined at normal limits. The average Ca levels measured in newborns were 10.1 ± 0.6 mg/dl and P levels 6.2 ± 1 mg/dl. In mothers without vitamin D, serum 25 (OH)D values are high (p = 0.02), in mothers without vitamin D, PTH values are high and osteocalcin values are low (respectively P = 0.02 and p = 0.03). In newborns who did not support their mothers with vitamin D, the PTH values were lower (P=0.004). Ca supplemented mothers were 25 (OH) D high (P = 0.009). The SOS values of newborns were 3127 ± 107 (2900-3389), the average Z score was 0.3 ± 0.7 (-1.4 - 2.6). A significant correlation has been observed between the newborn’s SOS scores and the Ca and ALP values. The evaluation of the bone structure by quantitative ultrasound is a non-invasive and practical method.

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