Objectives: The aim of this study is the documentation of human papilloma virus (HPV) frequency and types seen in the city of Istanbul, Turkey, as well as evaluation of the relationship between these subtypes and cytological and pathological diagnoses. Methods: 4879 cases were studied in our molecular pathology department between 2001 and 2019 in Istanbul. Between 2001 and 2010, 1692 cases were screened for HPV 6, 11, 16, 18, 31, and 33 by conventional hybridization and polymerase chain reaction (PCR). Since 2011, up to 49 HPV typing has been performed for 3187 cases with chip array. The cases were referred to the pathology center and the hospital pathology department by clinicians for screening before HPV vaccination and on the observation of precancerous changes and koilocyts in cytological-histopathological evaluations. Results: In this study, the frequency of HPV was found to be 10.8% (527 HPV-positive cases). Among these, 348 cases were high-risk groups, whether or not they were previously associated with a low-risk group. When we look at the distribution of the cases according to the high-risk HPV types, HPV 16 is the most common type. The frequencies of occurrence of other HPV types are as following: HPV–16: 41.7%, HPV–31: 11.7%, HPV–52: 7.9%, HPV–51: 7.1%, HPV–33: 6.9%, HPV–45: 6.5%, HPV–18: 6.3%, HPV–39: 6.1%, and HPV–58: 5.8%. It was further found that multiple infections were 28% of high grade squamous intraepithelial lesion cases. HPV frequency was 38% and 72%, respectively, in cases with cytologically or histopathological precancerous, low-grade squamous intraepithelial lesion, and HSIL changes. As a final note, HPV was detected in 9 of 10 cases with cervical cancer (90%). Only 1 adenocarcinoma case detected in the series was a double infection with HPV types 18 and 45. Conclusion: HPV 16 was the most common type found in this study. It is followed by types 31, 52, 51, 33, 45, 18, 39, and 58, respectively. The most common association observed in double infections was between HPV 16 and 58. It was also observed that the incidence of HPV in the city of Istanbul, Turkey, was similar to other developed countries. As a final note, in addition to screening tests, PCR and chip array studies should be conducted and the community should be informed about preventive medicine and the importance of condom use.
Purpose: In Turkey, in Istanbul, the frequency and types of HPV (Human Papilloma Virus) are documented, as well as the assessment of the relationship between these subtypes and the cytological and pathological diagnoses identified. Tools and Methods: In Istanbul, between 2001-2019 years, 4879 cases have been studied in our molecular pathology department. Between 2001 and 2010, 1692 incidents were scanned for HPV 6,11,16,18, 33 with classic hybridization and PCR (polymerase chain reaction). Since 2011, with chip array, HPV typography has been made for 3187 cases, which now reaches four decades. The incidents have been directed to the pathological center and the hospital pathology department in cytological-histopathological assessments on pre-cancerous changes and coylocytes or for scan purposes or by pre-HPV vaccination clinics. Results: In this study, the HPV rate was 10.8% (527 HPV-positive phenomena). There are 348 high-risk groups with low-risk groups or not. When we look at the distribution of cases according to high-risk types of HPV, HPV 16 (%41,7), HPV 31 (%11.7), HPV 52 (%7.9), HPV 51 (%7.1), HPV 33 (%6.9), HPV 45 (%6.5), HPV 18 (%6.3), HPV 39 (%6.1) and HPV 58 (%5.8). In cases of HSIL (high-degree squamous epithelial injury), the frequency of multiple infections is 28%. In cases with cytologically or histopathologically precancerous, LSIL (low-degree squamous epithelial injury) and HSIL changes, HPV frequency is 38% and 72% respectively. HPV has been diagnosed in nine of the 10 cases of cervical cancer (90%). The study found HPV 16 most frequently. It is followed by HPV 31, 52, 51, 33, 45, 18, 39 and 58. The most common association observed in double infections was between HPV 16 and 58. The prevalence of HPV in Istanbul is not very different from the developed countries. Scanning tests, PCR and chip array studies, as well as community-protectional medicine should be informed, the importance of preservative use should be emphasized (SETB-2021-01-022).
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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