Abstract:

Recurrent or periodic fever is seen frequently in pediatric medicine. Diagnostic criteria of PFAPA syndrome is cha- racterized by fever, cervical lymphadenopathy, aphthous stomatitis and pharyngitis. First case was a 8 year-old girl and she had recurrent attacks of fever, pharyngitis and aphthous stomatitis in every 3-4 weeks. Fever lasted 5-6 days and no response to antibiotics was received. Acute phase reactants elevated during the attacks and returned to normal between attacks. Symptoms of the patient dramati- cally returned to normal after single dose of prednisone. Second case was 3.5 year-old boy and he had recurrent attacks of membranous tonsillitis and high fever once a month. Cervical lymphadenopathy was observed in some of the attacks but without any aphthous stomatitis. Fever las- ted 5-6 days despite antibiotic use and acute phase reac- tants elevated. Symptoms of the patient returned to normal after a single dose of prednisone. We want both to empha- size PFAPA syndrome with two atypic patients and also review the literature

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