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NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES
2018
Journal:  
Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering
Author:  
DOI:  
10.18038/aubtda.335519
Abstract:

Thiophene belongs to a class of heterocyclic compounds. In this study, three new dimethyl-5-hydroxy isophtalate derived thiophene esters were successfully synthesized and characterized by FT-IR, elemental analysis, 1H-NMR, 13C-NMR and HR-Mass techniques. Synthesized compounds antimicrobial effects were tested on Staphylococcus aureus (ATCC 25923); Enterococcus faecalis  (ATCC 29212); Enterococcus faecalis (ATCC 51922); Klebsiella pneumoniae (ATCC 700603); Pseudomonas aeruginosa (ATCC 27853); Escherichia coli (ATCC 35218); Escherichia coli (ATCC 25922) and Candida albicans (ATCC 90028); Candida glabrata (ATCC 90030); Candida krusei (ATCC 6258); Candida parapsilosis (ATCC 22019). Compound C1 showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against, P. aeruginosa ATCC 27853. According to MTT assays, this compound was identified as non-toxic.

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Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering

Field :   Fen Bilimleri ve Matematik; Mühendislik; Sağlık Bilimleri

Journal Type :   Uluslararası

Metrics
Article : 661
Cite : 345
Quarter
Basic Field of Health Sciences
Q3
122/222
Basic Field of Science and Mathematics
Q4
107/135
Basic Field of Engineering
Q4
98/114
Details
Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering