Özet:

Bladder cancer is the second most common cancer of the genitourinary tumors. After initial TURB, %70 of patients with nonmuscle-invasive bladder cancer have develop one or more recurrences and one third of them will progress to invasive tumor. Muscle invaziv bladder cancer is a devastating disease since over 50% of the patients will die from metastatic disease. RAS genes are the member of oncogenes family. The main function of the ras proteins is to induce activation of protein kinase pathway, which in turn results in continuous mitogenic signaling and transformation of immortalized cells. Because of their active involvement in proliferative signals within the growing cell, ras genes are the most common targets for somatic mutations in urotelial tumors. RAS protooncogene mutations in the human cancers are the most common observed genetic alterations. In urothelial tumors somatic mutations in the ras genes may be of use for early detection of primary and recurrent tumors, for follow up targeted therapies in tissue-based assays. In this review, it was revised relations between RAS gene mutations and bladder cancer

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