Özet:

Aim: Gestational Diabetes (GDM) is glucose intolerance that is first diagnosed during pregnancy. Many risk factors such as advanced gestational age, multiparity, history of GDM in a previous pregnancy, and genetic factors have been defined for GDM, which increases the risk of complications in both mother and baby. In addition, some inflammatory mediators, chemokines, and polymorphisms of the genes encoding them are associated with GDM. In this study, we aimed to determine the relationship between GDM susceptibility and IL8/CXCL8 rs4073 (-251A/T) gene polymorphism by comparing the genotype and allele frequency distributions in pregnant women diagnosed with GDM and healthy pregnant women. Material and Methods: One hundred pregnant patients diagnosed with GDM and 100 healthy pregnant as the control group, were included in our study. All participants were followed up in Zonguldak Bülent Ecevit University Medical Faculty Hospital, Department of Obstetrics and Gynecology. Genotyping of the IL8/CXCL8 rs4073 gene polymorphism was determined using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method. The χ2 test was used to compare the genotype frequency of each gene polymorphism in GDM patients and controls. Results: There was no statistically significant difference between pregnant women with GDM and healthy pregnant women in terms of rs4073 polymorphism genotype and allele frequency distributions (p=0.260, p=1.000, respectively). Conclusion: Although our findings show that IL8/CXCL8 rs4073 gene polymorphism is not associated with susceptibility to GDM, further studies with large sample sizes including different ethnic groups and clinical parameters of participants such as body mass index and pre-pregnancy weight, are needed to confirm our findings

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