Abstract:

In this study, new chalcone derivatives containing sulfonamide were synthesized rapidly and efficiently. The synthesis of the chalcone skeletal structure was performed using the base-catalyzed Claisen-Schmidt condensation reaction method. Chalcone 3 was synthesized with 80% yield as a result of the reaction of 4-methoxy acetophenone, 4-nitrobenzaldehyde and NaOH. Reduction of the nitro functional group in compound 1-(4-methoxyphenyl)-3-(4-nitrophenyl)prop-2-en-1-one (3) with SnCl2.2H2O obtained the target compound 3-(4-aminophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (4) in 98% yield. The synthesis of target molecules that has the potential to be used in many different therapeutic applications, including Alzheimer's disease, has been successfully achieved as a result of the reaction of amine (4) with 3-(trifluoromethyl)benzenesulfonyl chloride, 4-fluorobenzenesulfonyl chloride, 4-methoxybenzenesulfonyl chloride, naphthalene-1-sulfonyl chloride, pyridine-3-sulfonyl chloride and methanesulfonyl chloride.

Keywords: