Abstract:

Detecting the pulmonary carcinoma spreading to the bone marrow is very useful for staging the disease, predicting possible prognosis and determining the treatment of choice. The biopsy of bone marrow is one of the convenient methods to detect any metastasis to bone marrow. Thus, during staging process prior to the treatment of small cell pulmonary carcinoma, it is recommended to perform a biopsy of bone marrow in the routine practice. The object of our study is to investigate the importance of bone-marrow aspiration and needle biopsy for diagnosing the pulmonary carcinoma and staging process prior to the treatment, frequency of bone-marrow metastasis, and assess laboratory and clinical changes in the cases with metastasis. A biopsy of bone-marrow showed that 7 cases (17.5 %) had a metastasis to bone marrow. According to histo -patological grading, of 25 cases with small cell pulmonary carcinoma and 15 cases with none-small cell pulmonary carcinoma, 24 % (6) and 6.6 % (1) had a metastasis to bone marrow, respectively. In this study, since small cell pulmonary carcinoma had an infiltration of bone marrow by 24 %, it was suggested that the biopsy of bone marrow was useful for staging process and diagnosing the disease accurately. As non-small cell pulmonary carcinoma had an involvement of bone marrow by 6.6 %, we suggested that the biopsy of bone marrow may be useful for the diagnose of those patients undiagnosed with other methods. There was statistically significant relationship between the involvement of bone marrow and bone metastasis, that is only among the far metastasis.

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