Özet:

Objective: COVID-19, which emerged in China at the end of December 2019, spread all over the world in a short time and was accepted as a pandemic by the World Health Organization on March 11, 2020. The pandemic is still up-to-date with its changing variants and number of cases. In this study, we aimed to determine the importance of hematological, inflammatory, and biochemical markers measured on the 1st and 5th days in inpatients with a diagnosis of COVID-19 in predicting mortality. Material And Methods: The research was designed as a retrospective and cross-sectional study. The study included 200 patients over the age of 18 who were admitted to Kahraman-maraş Sütçü İmam University Hospital between 1 November 2020 and 30 April 2021 with suspected symptoms of COVID-19, and the diagnosis was confirmed by the RT-PCR test. The patient's age, gender, comorbid diseases, 1st and 5th-day laboratory parameters, and out-come were recorded. The patients were divided into two groups discharged and deceased. Results: Of the 200 patients included in the study, 75% (n=150) were discharged and 25% (n=50) died within 28 days. 63.5% (n=127) of the patients were male and 36.5% (n=73) were female. The mean age of the patients was 63±17.2 years. Of the patients, 50.5% had mild, 31% moderate, and 18.5% severe clinical. Logistic regression analysis was performed to determine the factors affecting the prognosis of COVID-19 patients. Factors associated with prognosis were found to be male gender, presence of DM, presence of chronic obstructive pulmonary disease, presence of hypertension, fever, shortness of breath, and cough. Lymphocyte (lymphopenia), CRP (C-Reactive Protein), PCT (Procalcitonin), NLR (Neutrophil lymphocyte ratio), PLR (Procalcitonin lymphocyte ratio), D-Dimer values measured on the 1st and 5th days of the patients were found to be a predictor of mortality at the time of diagnosis and during follow-ups (p<0.005). Conclusion: In our study, it was determined that leukocyte, lymphocyte, NLR, PLR, CRP, PCT, ferritin, D-Dimer, and LDH values measured in COVID-19 patients were important parameters in predicting mortality at admission and during hospitalization. We think that these parameters will help the clinician in the follow-up of patients with COVID-19.