Özet:

In this study, the epidemiological and clinical characteristics of the 27 Ewing Sarcoma phenomenon, followed and treated in the Children's Hematology-Oncology Science Department, the results of treatment, long-term complications, were retrospectively studied. The average diagnosed age of cases (n=27) was 11.36 ±3.98 years (8 months - 17.9) and the male/woman ratio was 1.7. The most common approaches were localized pain (96.3%) and swelling (100%). The primary tumor area was detected in 16 cases (59.3%) in long bones, in 11 cases (40.7%) in acoustic bones. The bones in which the primary injury was placed were femur (26%), tibia (14.8%), pelvis (14.8%), and fibula (11.1% respectively). At the time of the application, 3 cases (11.1%) of the bone marrow was detected. In a total of 9 cases (33.3%) distant spread was detected during the diagnosis. In 23 cases (92) neoadjuvan chemotherapy, 17 cases (77.2) adjuvan chemotherapy was found. In 13 of the cases, end protection surgery, 2 were found to have been amputed. Radiotherapy was applied in 65.3% of cases (n=17) and the radiotherapy place was targeted in 11 cases to the primary tumor area, in 5 cases to the metastasis area, in 1 cases to both the primary tumor and the metastasis area. The average and average monitoring periods of the incidents were 35.5 and 19 months (maximum 355 months) respectively. The overall survival rate was found as 22.4 ± 10.9%. Retrospective assessment of patients with pediatric Ewing's sarcoma In this study, 27 patients with Ewing's sarcoma admitted to the Pediatric Hematology and Oncology Department were evaluated retrospectively. The epidemiological and clinical features, treatment results, long-term side effects of therapy of 27 patients with Ewing's sarcoma were analyzed. The average age of patients with Ewing's sarcoma (n=27) was 11.36 ±3.98 years (range,8 months-17.9 years) and male/female ratio was 1.7. The most common complaints were pain (96.3%) and swelling (100%). A total of 16 (59.3%) primary tumors were located in an extremity, whereas 11 (40.7%) occured in the axial skeleton. The most common primary lesion sites were femur (26%), tibia (14.8%), pelvis(14.8%) and fibula (11.1%) respectively. At diagnosis 3 patients (11.1%) had bone marrow metastases. A total of 9 patients (33.3%) had metastases at diagnosis. 23 patients (92%) received neoadjuvant chemotherapy and 17 patients received (77. 2 % of adjuvant chemotherapy. Limb salvage surgery was applied in 13 patients and amputation was made in 2 patients. Seventeen patients (65.3%) received radiotherapy; to the primary lesion site in 11 patients, the metastatic site in 5 patients, and both sites in one patient. The average and median follow-up of patients with Ewing's sarcoma was 35.5 and 19 months respectively (maximum 355 months). The overall survival rate was 22.4±10.9%.

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