Özet:

Objectives: Dalbergia sissoo (D. sissoo), a common medicinal plant for gastric and skin problems also has brain revitalizing effect as reported in ayurvedic literature but its neuroprotective effect has not been reported so far in amyloid β (Aβ) 1-42 model of Alzheimer disease (AD). The current study describes the protective effect of ethanolic extract of D. sissoo leaves (EEDS) against Aβ (1-42) induced cognitive deficit, oxidative stress and neuroinflammation in rats. Materials and Methods: EEDS (300 mg/kg and 500 mg/kg) was administered orally in rats for two weeks prior to intracerebroventricular (i.c.v.) Aβ (1-42) administration. The neuroprotective effect of EEDS was assessed by evaluating behavioural, biochemical and neuroinflammatory parameters in rat hippocampus. Memory function was assessed in Morris water maze task two weeks after Aβ (1-42) administration. After three weeks of surgery, all biochemical parameters were evaluated and histopathological examination of tissues was carried out. Results: EEDS improved the cognitive ability of Aβ (1-42)-administered rats in Morris water maze (MWM) task. It reduced oxidative stress by significantly declining the levels of nitrite and malondialdehyde (MDA) while elevating the levels of catalase and reduced glutathione (GSH) in rat brain. Further, EEDS mitigated neuroinflammation in rats by decreasing the concentrations of neuroinflammatory markers in a dose dependent manner. Conclusion: The study reveals that D. sissoo leaf extract has a beneficial role in alleviating cognitive deficits in AD by modulating cholinergic function, oxidative stress and neuroinflammation.

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