Abstract:

Nowadays it is observed the wide prevalence of polypous rhinosinusitis, associated with intolerance to aspirin. From today positions the main principle of pathogenesis is in presence of “genetic block” of constitutive cyclooxigenase – the node enzyme of metabolism of arachidonic acid that leads to its active accumulation. It leads to the disorder of lipid metabolism and conditions the necessity to study its biochemical features. Aim of research. To study biochemical parameters of the lipid exchange in patients with chronic polypous rhinosinusitis, associated with intolerance to acetylsalicylic acid by determination of the main metabolites. Materials and methods. The results of laboratory examination of 20 patients with aspirin associated polypous rhinosinusitis are presented in the article. The control group included 7 practically healthy donors. There were studied the level of arachidonic acid in condensate of exhaled air, arachidonic, linoleic, eicosapentaenoic acids, phospholipids, malonic dialdehyde and oxide modification of protein in the blood serum. Results. There were determined the changes of lipid exchange, which essence is in increase of the level of arachidonic acid in condensate of exhaled air and blood serum that leads to the decrease of the content of its main predecessors – linoleic and eicosapentaenoic acids and also phospholipids. The increase of arachidonic acid content stimulates the processes of peroxidation and leads to the increase of malonic dialdehyde content and oxide modifications of protein. The features of biochemical disorders testify to the proinflammatory direction of lipids metabolism. Conclusions. The received data confirm the hypothesis of “genetic block” of arachidonic acid metabolism as the main pathogenetic link of polypous rhinosinusitis, associated with intolerance to aspirin, and allow clearly interpret the clinical image and the features of clinical course.

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