Özet:

For drug delivery due to the simplicity of administration, patient comfort and pliability in the preparation oral drug delivery administration has been the uppermost route. Gastroretentive mucoadhesive tablet of combination of two drugs like Valsartan and Hydrochlorothiazide were prepared by using direct compression technique. Mucoadhesion is a complicated occurrence that includes wetting, adsorption and interpenetration of polymer chains. The formulated tablet of several preparation was characterized during a entire mucoadhesion time, resiliency delay time and percent drug liberation. The several batches were formulated by using a direct compression method utilizing the diversity of mucoadhesive polymers like Carbopol 971, Eudragit RS 100 and exposed to several evaluation variables like in-vitro drug release outline, tablet post compression parameters and physical possessions. The formulated tablet granules are assessed before compression during various parameters such as bulk density, tapped density, angle of repose, compressibility etc. to check the flow possessions of granules. In assessment of Post Compression variables of Gastroretentive high density tablets also various parameters are studied like Weight variation(mg), Friability (%), Hardness(kg/cm2 ), Thickness(mm), Drug Content of Valsartan (%), Drug Content of Hydrochlorothiazide (%) etc. The Gastroretentive Mucoadhesive tablet formulation shows best drug release pattern so it is considered as best formulation for the Gastroretentive sustained release drug delivery system. For the sustained release gastroretentive drug delivery system from the evaluation of all types of tablets it is concluded that the Mucoadhesive approach is the best. The stability study of optimized batch of mucoadhesive tablets shows that the formulation is stable.

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