Özet:

Diabetes mellitus is known to cause damage in various tissues and organs. It has been to cause cognitive functional disorders due to damage of the nervous system, in particular the central nervous system. However contradictory findings related to this condition are encountered in literature. This research was conducted on a total of 20 male rats, including a control group consisting of 10 young rats of Sprague Dawley and 2 months of age and an experimental group consisting of 10 rats in which diabetes was induced by means of streptozotocin administration. Experimental diabetes was induced by means of administering 60mg/kg streptozotocin (ip.) and their ability of spatial learning was evaluated by using a Morris water hall. The total duration of time spent to find the platform and the duration of time spent in the half of the field including the platform in a value representing the percentage in the total time were compared statistically within and between the rats included in the control and diabetic experiment groups so as to assess the effect of diabetes on the ability of learning to position in rats. The comparison of the learning phase for learning performance displayed on each day within groups was statistically analyzed by means of repeated measurements with the ANOVA test whereas the test phase was compared between groups with the unpaired t test. According to the evaluation, the learning performance of rats with induced diabetes was found to be better throughout the first four days after administration of streptozotocin in comparison to the rats included in the control group. The findings obtained in this research which point out to better learning performance in the acute phase of diabetes have been related to the absence of cell damage and occurrence of hyperglycemia in the acute phase

Anahtar Kelimeler: