Abstract:

Aim: It was aimed to compare the effects of tramadol and fentanyl for preemptive and intraoperative analgesia on hemodynamics, consumption of analgesics and muscle relaxants, recovery time and postoperative pain. Material and Methods: 120 patients scheduled for laparoscopic cholecystectomy were divided into four groups. Fentanyl bolus (Group FB) and infusion (Group FI) groups received 2 μgkg-1 fentanyl, and tramadol bolus (Group TB) and infusion (Group TI) groups received 2 mgkg- 1 tramadol intravenously, followed by induction of propofol and rocuronium. After intubation, 0.5 μg kg-1 hour-1 of fentanyl and 0.5 mg kg-1 hour-1 of tramadol were administered to the Groups FI and TI, respectively. If additional intraoperative analgesia was required, in Groups FB and FI 0.5 μgkg-1 fentanyl, in Groups TI and TB 0.5 mgkg-1 tramadol were administered. Meperidine and, if necessary, diclofenac were administered with a postoperative visual analog scale (VAS) score of >5 points. Hemodynamic data, fentanyl and tramadol consumption, postoperative recovery time, VAS scores and analgesic drugs recuirement were recorded. Results: After induction, mean arterial pressure (MAP) was lower in fentanyl groups (p <0.05). After intubation, heart rate and MAP increased more in tramadol groups (p <0.05). Intraoperative analgesics consumption was higher in infusion groups (p <0.05). Consumption of muscle relaxants was higher in tramadol groups (p <0.05). At the postoperative 5th and 60th minutes, Group FB had a higher VAS score and analgesics requirement and lower MAPs (p <0.05). Conclusion: It was concluded that post-intubation hemodynamic responses were better-maintained in fentanyl groups. and that preemptive and intraoperative bolus administrations of fentanyl were insufficient to provide analgesia in the postoperative period.

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