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Tiazolidin’in Zebra Balığı (Danio rerio) Solungaç ve Karaciğer Dokusunda AChE Enzim Aktivitesi ve Toplam Protein Seviyesi Üzerine Etkileri
2022
Journal:  
Acta Aquatica Turcica
Author:  
Abstract:

Bu çalışmanın amacı, tiazolidin’in (Tiazolidin-4-karboksilik asit (4S)-2- (4-hidroksi-3-metoksifenil) zebra balığı (Danio rerio) solungaç ve karaciğer dokusunda asetilkolinesteraz enzim (AChE) aktivitesi ve total protein (TP) düzeyleri üzerindeki etkilerinin araştırılmasıdır. Zebra balıkları tiazolidin’in 0,2 ppm, 0,4 ppm ve 0,6 ppm farklı dozlarına 96 saat süreyle maruz bırakılmıştır. AChE enzim aktivitesi karaciğer dokusunda, tiazolidin’in 0,2 ppm, 0,4 ppm ve 0,6 ppm doz gruplarında, kontrol grubuna oranla artmıştır. Solungaç dokusunda ise, tiazolidin’in 0,2 ppm, 0,4 ppm ve 0,6 ppm doz gruplarında, kontrol grubuna oranla AChE enzim aktivitesinin azaldığı görülmüştür. Total protein seviyesi karaciğer dokusunda, tiazolidin’in 0,2 ppm, 0,4 ppm ve 0,6 ppm doz gruplarında, kontrol grubuna oranla azalmıştır. Solungaç dokusunda ise, tiazolidin’in 0,2 ppm, 0,4 ppm ve 0,6 ppm doz gruplarında, kontrol grubuna oranla total protein seviyelerinin önemli sayılabilecek oranda arttığı görülmüştür. Sonuç olarak, bu araştırmada tiazolidinin zebra balığı solungaç ve karaciğer dokuları üzerinde az da olsa zararlı etkilere neden olabileceği görülmüştür.

Keywords:

Effects Of Thiazolidine On Ache Enzyme Activity and Total Protein Level In Zebrafish (danio Rerio) Gill and Liver Tissue
2022
Author:  
Abstract:

The aim of this study was to investigate the effects of thiazolidine (4S)-2-(4-hydroxy-3-methoxyphenyl) thiazolidine-4-carboxylic acid) on acetylcholinesterase enzyme (AChE) activity and total protein (TP) levels in zebrafish (Danio rerio) gill and liver tissue. Zebrafish were exposed to 0.2 ppm, 0.4 ppm and 0.6 ppm different doses of thiazolidine for 96 hours. AChE enzyme activity increased in liver tissue in 0.2 ppm, 0.4 ppm and 0.6 ppm dose groups of thiazolidine compared to the control group. In the gill tissue, AChE enzyme activity was decreased in 0.2 ppm, 0.4 ppm and 0.6 ppm dose groups of thiazolidine compared to the control group. Total protein level in liver tissue decreased in 0.2 ppm, 0.4 ppm and 0.6 ppm dose groups of thiazolidine compared to the control group. In the gill tissue, total protein levels were significantly increased in the 0.2 ppm, 0.4 ppm and 0.6 ppm dose groups of thiazolidine compared to the control group. In conclusion, it was seen that thiazolidine may cause some harmful effects on zebrafish gill and liver tissues in this study.

Keywords:

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Acta Aquatica Turcica

Field :   Fen Bilimleri ve Matematik; Ziraat, Orman ve Su Ürünleri

Journal Type :   Uluslararası

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Acta Aquatica Turcica