Abstract:

The aim of this study is to determine the effect on biochemical parameters after the application of tolphenamic acid in goats in single increased doses. The study used 18 healthy goats (2 0.4 years old and 38 3 kg body weight). Tolfenamic acid 2, 4 and 8 mg/kg were administered in a single dose intravenous (IV) way. Blood samples were taken at 72 hours before and after the application of tolfenamic acid. The serum levels of albumin, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamiltransferase (GGT), cholesterol, creatine, triglyceride, total protein and urine were measured in the autoanalytic device. No differences were identified in group and inter-group assessments of albumin, ALP, ALT, AST, GGT, cholesterol, creatine, triglyceride, total protein and urine values after IV application in doses of 2, 4 and 8 mg/kg (P>0.05). As a result, the single dose IV of 2, 4 and 8 mg/kg of tolphenamic acid in goats was not found to cause substantial changes in biochemical parameters. However, the reliability of tolphenamic acid in goats is needed to be determined at molecular and histopathological levels.

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