Özet:

Anjiotensin I-reversive enzyme is one of the important genes associated with physical activity in polymorphism. The aim of this study is to determine whether there is a relationship between ADE I/D gen polymorphism and athletic performance and ADE genotype distribution and maximum oxygen consumption (Vo2max). ADE I/D gen polymorphism was studied in 46 elite Turkish fighters and 58 healthy sedanter individuals. The Vo2max values of the elite fighters were measured by the hard run test. The DNA of elite fighters and sedanter individuals was obtained from peripheral blood. ADE I/D gen polymorphism was determined by alel frequencies and genotype distribution by polymerase chain reaction. The alel frequencies and genotype distribution of ACE I/D gen polymorphism of elite fighters and sedanter individuals were compared and there was no significant difference between elite fighters and sedanter individuals (P>0.05). There was no difference between the elite struggling ADE I/D gen polymorphism genotype distribution and Vo2max levels (P>0.05). Vo2max levels were identified with similar distribution in DD, ID and II genotype elite fighters. This study has shown that there is no meaningful relationship between ADE I/D gen polymorphism and sports performance and ACE I/D gen polymorphism genotypes and Vo2max.

Özet:

The polymorphism of angiotensin I-converting enzyme gene is one of the important genes associated with physical activity, The aim of this study is to determine whether there is a relationship between ACE I/D gene polymorphism and athletic performance and genotype distribution of the ACE gene and maximum oxygen consumption (Vo2max) in the elite Turkish wrestlers. ACE I/D gene polymorphism is investigated in 46 elite Turkish wrestlers and 58 healthy sedentary individuals. Vo2max values in elite wrestlers were measured by a progressive shuttle run test. DNA of elite wrestlers and sedentary individuals was obtained from peripheral blood. The allele frequencies and genotype distribution of ACE I/D gene polymorphism determined by polymerase chain reaction. Allele frequencies and genotype distribution of ACE I/D gene polymorphism in the elite wrestlers and sedentary individuals were compared and no significant difference was found between elite wrestlers and sedentary individuals (P>0.05). There was also no difference between the genotype distribution of the ACE I/D gene polymorphism and Vo2max levels in the elite wrestlers  (P>0.05). It was determined that Vo2max showed similar distribution in elite wrestlers with DD, ID and II genotypes. The present study demonstrated that there was no significant relationship between the ACE I/D gene polymorphism and sports performance and genotypes of ACE I/D gene polymorphism and Vo2max in elite Turkish wrestlers.

Anahtar Kelimeler: