Özet:

Aim: A substantial portion of colon cancer is diagnosed at stage II or III. While high survival rates are obtained with curative surgery in stage I, conversely, in stage IV curative surgery has no place, and survival rates are significantly lower despite chemotherapy. Survival rates vary greatly in stage II and III colon tumors, which are treated with combination of curative surgery and chemoterapy. This study aimed to analyse the prognostic factors on survival of stage II-III colon cancers. Method: One hundred seventy four patients with stage II or III colon cancer in the follow-up of Dokuz Eylül University Faculty of Medicine Oncology Clinic between January 1999 and August 2010 were included in the study. Prognostic factors defined in the literature were investigated retrospectively in this patient population. The factors that were found to be significant according to the univariate analysis were evaluated by multivariate analysis and independent factors were found. Results: In univariate analysis, presence of obstruction or perforation at admission, preoperative high carcinoembryonic antigen level, presence of lymphatic invasion (LI) and inadequate number of total lymph nodes removed were the poor prognostic indicators for disease-free survival. Of these, the presence of obstruction or perforation at admission was the only independent prognostic factor in multivariate analysis. Inadequate number of total lymph nodes removed and presence of LI were found to be associated with decreased overall survival in both univariate and multivariate analyzes. Conclusion: Presence of obstruction or perforation at admission, inadequate number of total lymph nodes removed and the presence of LI were associated with poor prognosis in patients with stage II and III colon cancer.

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