Özet:

Objectives: An increasing amount of epidemiological and experimental evidence has been carried out on the relationship between free radical activity and malignancy. The imbalance between free radical production and cellular defense mechanisms has been described in cancers and degenerative diseases like tuberculosis (tb). Methodology: The present investigation has been undertaken to study the levels of lipid peroxide (LP) and antioxidant enzyme superoxide dismutase (SOD) activities in sera of lung cancers (Lc) and tb. Forty-two patients and fourteen healthy cases were enrolled into the study. Group I had seventeen subjects with Lc, group II had twenty-five patients with tb and group III had fourteen healthy cases. The malondialdehide (MDA) and superoxide dismutase (SOD) activities in sera were quantified. Results: Serum MDA levels in the whole group of patients (Lc and tb) were much higher than in healthy controls. The levels of MDA did not change significantly in the group I vs. group II (p>0,05). The SOD activity in sera from patients with Lc was markedly lower than the other two groups. Activities of SOD in group I significantly decreased as compared to the group II (p<0,001). In the present study although LP levels increased in both tb and Lc patients, the activities of SOD in Lc cases were significantly higher than tb patients.

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