Özet:

Ankylosing spondylitis (AS) is a type of chronic inflammatory arthritis resulting in ankylosis of the spine and inflammation of the tendons. In this study, we aimed to investigate the usability of hematological parameters to determine disease activity in AS patients. Materials and Methods: A total of 65 patients who were previously diagnosed with AS were registered retrospectively in the current study. Patients were divided into two groups according to their Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores. Thirty-one patients who had BASDAI score > 5 served as "active AS" and 34 patients who had BASDAI score < 5 served as "inactive AS". Patients data including their physical examination findings were recorded. Medications, demographic properties, and laboratory findings of the patients were also recorded. Results: The clinical and demographic features of both groups were comparable. There were no differences between groups according to the use of medications, the duration of AS and the presence of uveitis, enthesopathy, and peripheral arthritis. In laboratory findings, the Erythrocyte Sedimentation Rate (ESR), C-reactive Protein (CRP) and Neutrophil/Lymphocyte Ratio (NLR) were significantly higher, Mean Platelet Volume (MPV) was significantly lower in active AS group than in inactive AS group. In the correlation analysis, the BASDAI score had a significantly negative correlation with MPV (r=-0.309, p=0.012) and significantly positive correlations with ESR, CRP and N/L values (r=0.427, p<0.001, r=0. 328, p=0.008 and r=0.316, p=0.010, respectively). In linear regression analysis, only MPV score was found to be a predictor for AS activity (p<0.04).Conclusion: Mean platelet volume is significantly negative correlated with BASDAI score and could provide a clue for primary care physician which patients who are at high risk for AS activity. Ankylosan spondylitis (AS) is a type of chronic inflammatory arthritis that causes ankylosis in the spine and creates inflammation in the tendons. In this study, we studied the availability of hematological parameters in showing the activity of the disease in AS patients. Tools and Methods: The study included a total of 65 patients followed by previous AS diagnosis as retrospective. According to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), patients were divided into two groups. A total of 31 patients with a BASDAI score> 5 were classified as inactive AS and a total of 34 patients with a BASDAI score < 5. The data of all patients, including the results of detailed physical examination, was recorded. The patient’s drug use, demographic and laboratory data were also recorded. The two groups were similar in terms of clinical and demographic characteristics. There is also no statistical difference between the two groups in terms of the history of drug use, the age of the disease, the presence of ovulation, the presence of entesopathy and the presence of peripheral arthritis. The rate of erythrosite sedimentation (ESH), C-reactive protein (CRP) and neutrophil/lenphocytes (NLR) in the active AS group was significantly high compared to the inactive AS group, while the average platelet volume (OPH) was significantly low. In correlation analysis, the BASDAI score had a clear positive correlation with OPH (r=-0,309, p=0,012), ESH, CRP and NLR (r=0,427, p<0,001, r=0,328, p=0,008 and r=0,316, p=0,010 respectively). When these variables were introduced into linear regression analysis, it was found that only OPH predicted AS disease activity (p<0,04). The result: OPH is clearly negative with the BASDAI score indicating disease activity, and the first stage can provide a clue for family doctors which patients are at high risk for AS activity.

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