Özet:

Objective: Diabetic foot ulcers, one of the factors that determine the life time and quality of life in diabetic patients are one of the most frequent causes of hospitalization and surgery. In this study, we aimed to investigate the levels of interleukin (IL)-12 P70, 17, 18, hemoglobin (Hb) A1c, and some parameters in subjects with type 2 diabetes mellitus with diabetes foot and in healthy subjects. Methods: The study was performed on three groups. They were patients with diabetes foot, with diabetes mellitus type 2 and healthy individuals (control). IL-12 P70, IL-17, and IL-18, HbA1c levels and other biochemical parameters were compared between three groups. Results: We found higher IL-17, IL-18, white blood cells, glucose and HbA1c in the diabetes group and diabetes foot group than in the control group. IL-12 P70 levels in the diabetic foot group were significantly higher than the control group. The performance in diagnosing of IL-12 P70, 17 and 18 as a biomarker for diabetic foot were found statistically significant. IL-12 P70, 17 and 18 levels in diabetic patients were not different from the levels in diabetic foot patients. Conclusion: According to our results, IL-12 P70, IL-17 and IL-18 can be used as biomarkers for diabetic foot. Further studies are needed to show the role of IL-12 P70, IL-17 and IL-18 levels as a biomarker in chronic inflammatory diseases.