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Abstract Introduction: Safe induction of anesthesia is important part of anesthesia practice as life threatening hemodynamic variations may occur during induction and intubation in hemodynamically unstable patients. Present prospective randomized observational study was conducted to compare the hemodynamic effects of etomidate and propofol during induction and intubation.Material and Methods: This study was conducted on 90 patients of ASA grade I and II scheduled for elective surgical procedure under general anesthesia with endotracheal intubation. Patients were randomly assigned into 2 groups of 45 patients each.Group E (n = 45) received Inj. Etomidate (0.3 mg/kg of body weight) and Group P (n = 45): received Inj. Propofol 1% (2 mg/kg of body weight). Vital parameters at induction, laryngoscopy and thereafter recorded for comparison. Adverse effects like pain on injection, apnea and myoclonus were carefully noted.Results:Both groups have comparable demographic variables.Patients in etomidate group showed little change in mean arterial pressure (MAP) and heart rate (HR) compared to propofol (p > 0.05) from baseline value. Pain on injection was more in propofol group while myoclonus activity was higher in etomidate group.Conclusion:Through this study, we concluded that etomidate is hemodynamically more stable than propofol with less incidence of pain on injection. Keywords:Induction, intubation, etomidate, propofol, hemodynamic stable.

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