Abstract:

OBJECTIVE: We aimed to test the hypothesis that using of 50 % nitrous oxide/oxygen mixture intraoperatively could reduce the postoperative analgesic requirements and prevent acute pain to chronic in patients undergoing hysterectomyMETHODS: Patients aged between 18-70 years ASA I-III undergoing hysterectomywere enrolled. Following standart anesthesia induction, maintenance of anesthesia was provided in Group N (n=30) with 50% nitrous oxide/oxygen mixture in the 1-2% sevoflurane and in Group H with 50% air/oxygen mixture in the 1-2% sevoflurane. Patient demographic datas, comorbidities and the duration of the operations were recorded. Tramadol infusion with patient controlled analgesia (PCA) device was started in all patients at the end of the surgery. Additional analgesic diclofenac sodium implementation was planned in patient whose Visual Analogue Scale (VAS) scores were over 4. Heart rate (HR), mean arterial pressure ( MAP), peripheral oxygen saturation ( SpO2 ), and VAS scores were recorded at 0, 4, 12, and 24 hours postoperatively. Ramsey scores were recorded t 0 and 30.minute in recovery room and 4 and 12 hours postoperatively. Also, given additional analgesics, opioid consumptions within 24 hours were recorded. 4 and 12 weeks after surgery, patients pain that limits daily activities (VAS 0-10 ) (if applicable: 1 or 0 ) were asked with telephone interviews and then recorded.RESULTS: Opioid consumption and additional analgesic given patients were significantly lower in Group N. VAS values that evaluated at all times were significantly lower in Group N (p

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