Özet:

The antioxidant and radioprotective effects of propolis against radiation-related oxidative damage have been studied. Twenty rats were divided into 3 groups; 1st group control group; 2nd group radiation group; serum physiological (i.p.3 days + 9 Gy gamma radiation; 3th group radiation + propolis group; propolis (i.p. 100 mg/kg CA) for 3 days + 9 Gy gamma radiation was applied. As a result of radiation, a significant increase in the levels of malondaldehyde (MDA) in the liver, kidney and brain tissues of rats was observed (P<0.001). All tissues had a significant decrease in glutation peroxidase (GSH-Px) activity (P0.001) and in the liver with hyperoxide dismutase (SOD) activity and glutation (GSH) levels (P0.01). Also, the level of GSH in the tissues of the kidneys (P0.001) and the ovarian (P0.05) increased significantly. In addition to propolis, the increased MDA levels in the liver decreased significantly as a result of radiation (July 0.001), while the increased MDA levels in the kidneys and the brain did not change. In the liver and ovarian tissues, the MDA values were significantly reduced compared to the radiation group, in addition to propolis (July 0.05). In addition to propolis, radiation resulted in a decrease in the liver (July0.01), while increasing levels of GSH in the kidneys approached control levels (July0.001), increased levels of GSH in the wheat and the brain were observed according to both control and the group of radiation applied (July0.05). The supplementation of propolis caused a decrease in the activity of both the control and radiation in the cardiovascular, cavity, brain, ovarian GSH-Px according to the group applied (February 0.001). In addition, there was a significant reduction in heart SOD activity according to the control group (P0.05).

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